Permeability enhancers for negatively charged polynucleotides

Details Permeability enhancers for negatively charged polynucleotides Permeability enhancers for negatively charged polynucleotides

1993-11-19

1996-12-10

Stone, Jacqueline M.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

514 44, 5483351, 560 1, 564230, 564384, 564463, 564509, C12N 1500, A61K 3170, C07D23316

Patent

active

055830200

ABSTRACT:
This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.

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Ryser, Hugues J.-P., "A Membrane Effect of Basic Polymers dependent on Molecular Size," Nature215:934-936 (1967).
Lemaitre et al., "Biological Activities of Oligonucleotides Linked to Poly(L-Lysine)," Nucleosides & Nucleotides 6:311-315 (1987).
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