Permanent human hepatocyte cell line and its use in a liver assi

Details Permanent human hepatocyte cell line and its use in a liver assi Permanent human hepatocyte cell line and its use in a liver assi

1992-10-23

1994-03-01

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

4352402, 43524023, 435240242, C12Q 102, C12N 500

Patent

active

052906841

ABSTRACT:
Permanent cell lines are provided which display liver-specific biological activity at a level effective to support a subject suffering from hepatic failure or insufficiency. The cells find use in treating various liver disorders. An example of the cell lines is HepG2/C3A deposited under ATCC No. CRL-10741. Methods for use of the cells in liver assist devices and methods for producing liver assist devices are also provided.

REFERENCES:
patent: 3935066 (1976-01-01), Apostolov
patent: 4393133 (1983-07-01), Knowles
patent: 4416986 (1983-11-01), Markus
patent: 4853324 (1989-08-01), Viles
Bertolotti, R., A Selective System for Hepatoma Cells . . . Somatic Cell Genetics, 3 #4, 1977, pp. 365-380.
Knowles, Human Heptacellular Carcinoma Cell Lines . . . Science, vol. 209, 25 Jul. 1980, pp. 497-499.
Miura Y., In Vitro Maintenance of Terminal . . . Artificial Organs 11(5): 361-365, 1987.
Saito S., A New Hybrid Artificial Liver Using . . . Trans Am Soc Artif Intern Organs 33: 459-462 (1987).
Gerlach, Use of Hepatocytes in Adhesion & Suspension . . . Inter J. Artif Organs 12; 788-792 (1989).
Zhai, W., A Nude Mouse Model for the In Vivo Production . . . Gastro 98 (1990) pp. 470-477.
Yanagi K., Performance of a New Hybrid Artificial . . . Trans Am Soc Artific Internal Organs 35: 570-572 (1989).
Chui, J., The Formations of Bile Canaliculi in Human . . . Hepatology 11 (5) 1990, pp. 834-842.
Sussman et al, Hepatology, 16(1): 60-65 (1992).
Kelly et al, Artif. Organs, 16(4): 418-422 (1992).
Kelly et al, Hepatology, 15(2): 329-336 (1992).

Affiliated with

Also associated with

Rating

Permanent human hepatocyte cell line and its use in a liver assi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Permanent human hepatocyte cell line and its use in a liver assi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Permanent human hepatocyte cell line and its use in a liver assi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-576306