Multicellular living organisms and unmodified parts thereof and – Method of making a transgenic nonhuman animal – Involving breeding to produce a double transgenic nonhuman...
Reexamination Certificate
2007-12-18
2007-12-18
Kaushal, Sumesh (Department: 1633)
Multicellular living organisms and unmodified parts thereof and
Method of making a transgenic nonhuman animal
Involving breeding to produce a double transgenic nonhuman...
C800S003000, C800S009000, C800S014000, C800S018000, C800S021000
Reexamination Certificate
active
11481568
ABSTRACT:
The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding transgene. A method of screening for a compound which alters the rate or extent of amyloid deposition is additionally provided. The method consists of: (a) constructing a perlecan transgenic animal; (b) administering an effective amount of a test compound to said perlecan transgenic animal; and (c) determining whether said test compound alters the extent or rate of amyloid deposition. Finally, the invention provides a method of screening for a compound which alters the rate or extent of amyloid deposition. The method consists of: (a) constructing a perlecan/amyloid double-transgenic animal; (b) administering an effective amount of a test compound to said perlecan/amyloid double-transgenic animal; and (c) determining whether said test compound alters the extent o rate of amyloid deposition.
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Fukuchi Ken-Ichiro
Hassell John
Snow Alan D.
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