Peritoneal dialysis solutions and methods usable to minimize the

Details Peritoneal dialysis solutions and methods usable to minimize the Peritoneal dialysis solutions and methods usable to minimize the

1996-08-16

1999-09-21

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 514 53, 514561, A61K 3170

Patent

active

059554509

ABSTRACT:
Peritoneal dialysis solutions are specially formulated for use during and immediately after an episode of peritonitis. The solutions include one or more additives to minimize the injury and physiological effects that peritonitis can cause. One additive is a mixture of amino acids sufficient to maintain a positive nitrogen balance, at least one of the amino acids being present in a dipeptide form. Another additive is a compound that scavenges free radicals generated by peritoneal macrophages activated by the peritonitis. Another additive is chondroitin sulfate that changes the permeability of the peritoneal membrane during subsequent dialysis using solutions free of chondroitin sulfate. Another additive is the degradation products of hyaluronic acid to enhance the regeneration of the peritoneal mesothelium without fibrosis.

REFERENCES:
patent: 5108767 (1992-04-01), Mulchandani et al.
patent: 5597805 (1997-01-01), Breborowicz

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