Peripherally active anti-hyperalgesic opiates

Details Peripherally active anti-hyperalgesic opiates Peripherally active anti-hyperalgesic opiates

1995-09-12

1998-12-15

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

058497617

ABSTRACT:
Methods using compositions for the treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit central nervous system side effects. The anti-diarrheal compound 4-(p-chlorophenyl)-4-hydroxy-N-N-dimethyl-.alpha.,.alpha.-diphenyl-1-piper idinebutyramide hydrochloride is preferred for use in the compositions of the claimed methods.

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