Peripherally active anti-hyperalgesic opiates

Details Peripherally active anti-hyperalgesic opiates Peripherally active anti-hyperalgesic opiates

1998-11-24

2000-12-26

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514326, 514316, 5142372, A61K 31445

Patent

active

061660396

ABSTRACT:
Methods for treatment of peripheral hyperalgesia are provided, comprising administering compositions containing an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit central nervous system side effects. The anti-diarrheal compound 4-(.rho.-chlorophenyl)-4-hydroxy-N-N-dimethyl-.alpha.,.alpha.-diphenyl-1-p iperidinebutyramide hydrochloride is preferred for use in the methods.

REFERENCES:
patent: 3275510 (1966-09-01), Magid et al.
patent: 3714159 (1973-01-01), Janssen et al.
patent: 3789072 (1974-01-01), Bernstein
patent: 3884916 (1975-05-01), Janssen et al.
patent: 3914238 (1975-10-01), Soudijn et al.
patent: 3950537 (1976-04-01), DeBenneville et al.
patent: 3996214 (1976-12-01), Dajani et al.
patent: 3998832 (1976-12-01), Adelstein et al.
patent: 4012374 (1977-03-01), Wade et al.
patent: 4012393 (1977-03-01), Markos et al.
patent: 4013668 (1977-03-01), Adelstein et al.
patent: 4025652 (1977-05-01), Diamond et al.
patent: 4057549 (1977-11-01), Adelstein et al.
patent: 4060635 (1977-11-01), Diamond et al.
patent: 4066654 (1978-01-01), Adelstein et al.
patent: 4069223 (1978-01-01), Adelstein et al.
patent: 4072686 (1978-02-01), Adelstein et al.
patent: 4115564 (1978-09-01), Diamond et al.
patent: 4116963 (1978-09-01), Adelstein et al.
patent: 4125531 (1978-11-01), Yen
patent: 4147804 (1979-04-01), Diamond et al.
patent: 4160099 (1979-07-01), Bodor
patent: 4194045 (1980-03-01), Adelstein
patent: 4203920 (1980-05-01), Diamond et al.
patent: 4218454 (1980-08-01), DeGraw et al.
patent: 4238390 (1980-12-01), Meienhofer et al.
patent: 4269843 (1981-05-01), DeGraw et al.
patent: 4277605 (1981-07-01), Buyniski et al.
patent: 4326074 (1982-04-01), Diamond et al.
patent: 4326075 (1982-04-01), Diamond et al.
patent: 4328803 (1982-05-01), Pape
patent: 4371463 (1983-02-01), Pert et al.
patent: 4384000 (1983-05-01), Lanier
patent: 4407794 (1983-10-01), Roques et al.
patent: 4416886 (1983-11-01), Bernstein
patent: 4430327 (1984-02-01), Frederickson
patent: 4493848 (1985-01-01), LaHann et al.
patent: 4517295 (1985-05-01), Bracke et al.
patent: 4533739 (1985-08-01), Pitzele et al.
patent: 4626539 (1986-12-01), Aungst et al.
patent: 4749706 (1988-06-01), Lawson et al.
patent: 4824853 (1989-04-01), Wals et al.
patent: 4870084 (1989-09-01), Eggler et al.
patent: 4871750 (1989-10-01), Roberts
patent: 4892735 (1990-01-01), Harrap
patent: 4897260 (1990-01-01), Ross et al.
patent: 4898873 (1990-02-01), Wals et al.
patent: 4917896 (1990-04-01), Peck et al.
patent: 4939142 (1990-07-01), Budai et al.
patent: 4990521 (1991-02-01), Van Daele et al.
patent: 5039642 (1991-08-01), Chrobaczek
patent: 5069909 (1991-12-01), Sharma et al.
patent: 5100903 (1992-03-01), Lalinde et al.
patent: 5109135 (1992-04-01), D'Ambra et al.
patent: 5112596 (1992-05-01), Malfroy-Camine
patent: 5116847 (1992-05-01), Gilbert et al.
patent: 5116868 (1992-05-01), Chen et al.
patent: 5143938 (1992-09-01), Calvet et al.
patent: 5149538 (1992-09-01), Granger et al.
patent: 5202130 (1993-04-01), Grant et al.
patent: 5214080 (1993-05-01), Iwamura et al.
patent: 5229127 (1993-07-01), McKinzie
patent: 5236947 (1993-08-01), Calvet et al.
patent: 5240932 (1993-08-01), Morimoto et al.
patent: 5242944 (1993-09-01), Park et al.
patent: 5248505 (1993-09-01), Garwin
patent: 5266465 (1993-11-01), Rubin et al.
patent: 5273056 (1993-12-01), McLaughlin et al.
patent: 5273751 (1993-12-01), Dubroff
patent: 5278126 (1994-01-01), Katano et al.
patent: 5282851 (1994-02-01), Jacob-LaBarre
patent: 5286751 (1994-02-01), Sunshine et al.
patent: 5292362 (1994-03-01), Bass et al.
patent: 5300648 (1994-04-01), Emonds-Alt et al.
patent: 5312899 (1994-05-01), Schiller
patent: 5345943 (1994-09-01), Hargreaves et al.
patent: 5354863 (1994-10-01), Dappen et al.
patent: 5366979 (1994-11-01), Lawson
patent: 5369131 (1994-11-01), Poli et al.
patent: 5384124 (1995-01-01), Courteille et al.
patent: 5387688 (1995-02-01), Feldman et al.
patent: 5403867 (1995-04-01), Okumura et al.
patent: 5432176 (1995-07-01), Walser
patent: 5434292 (1995-07-01), Saita et al.
patent: 5436009 (1995-07-01), Jauw et al.
patent: 5437994 (1995-08-01), Emerson et al.
patent: 5446052 (1995-08-01), Emonds-Alt et al.
patent: 5446070 (1995-08-01), Mantelle
patent: 5460821 (1995-10-01), Masiz
patent: 5478814 (1995-12-01), Packman
patent: 5589480 (1996-12-01), Elkhoury et al.
patent: 5618557 (1997-04-01), Wille et al.
patent: 5645854 (1997-07-01), Masiz
patent: 5646151 (1997-07-01), Kruse et al.
patent: 5667773 (1997-09-01), Farrar et al.
patent: 5686106 (1997-11-01), Kelm et al.
patent: 5688955 (1997-11-01), Kruse et al.
patent: 5744458 (1998-04-01), Kruse et al.
patent: 5760023 (1998-06-01), Farrar et al.
patent: 5763445 (1998-06-01), Kruse et al.
patent: 5798093 (1998-08-01), Farrar et al.
patent: 5811078 (1998-09-01), Maycock et al.
patent: 5834480 (1998-11-01), Elkhoury
patent: 5849761 (1998-12-01), Yaksh
patent: 5849762 (1998-12-01), Farrar et al.
patent: 5855907 (1999-01-01), Peyman
patent: 5866143 (1999-02-01), Elkhoury
patent: 5869521 (1999-02-01), Farrar et al.
patent: 5888494 (1999-03-01), Farrar et al.
patent: 5919473 (1999-07-01), Elkhoury
patent: 5945443 (1999-08-01), Kruse et al.
patent: 5962477 (1999-10-01), Mak
patent: 5981513 (1999-11-01), Kruse et al.
patent: 5994372 (1999-11-01), Yaksh
Abbott, "Peripheral and central antinociceptive actions of ethylketocyclazocine in the formalin test." Eur. J. Pharmacol. 142:93-100 (1988).
Acne in Teens: Ways to Control it, AAFP patient education brochure series, Health Notes from Your Family Doctor, (1994).
Adelstein, Gilbert W., et al., "3,3-Diphenyl-3-(2-alkyl-1,3,4-oxadiazol-5-yl)propylcycloalkylamines, a Novel Series of Antidiarrheal Agents," J. Med. Chem. 19:1221-1225, (1976).
Alreja, et al., The formalin test: A tonic pain model in the primate, Pain, 20:97-105 (1984).
Andreev et al., "Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet radiation." Neuroscience 58(4):793-798 (1994).
Ansel et al., "Cytokine modulation of keratinocyte cytokines", J. of Inv. Derm. 94(6):101-107 (1990).
Antonijevic, et al., Perineurial defect and peripheral opioid analgesia in inflammation, J. Neurosci., 15(1):165-172 (1995).
Atwouters, et al., "Loperamide: Survey of studies on mechanism of its antidiarrheal activity," Dig. Dis. and Sci. 38(6):977-995, (1993).
Atwouters et al., "Pharmacology of antidiarrheal drugs." Ann. Rev. Pharmacol. Toxicol. 23:279-301 (1983).
Bergfeld, et al., The evaluation and management of acne: Economic considerations, J. Am. Acad. Dermatol. 32(5)S52-56 (1995).
Berrebi et al., "Verapamil inhibits B-cell proliferation and tumor necrosis factor release and induces a clinical response in B-cell chronic lymphocytic leukemia", Leukemia 8(12):2214-2216 (1994).
Berson, et al., The treatment of acne: The role of combinantion therapies, J. Am. Acad. Dermatol. 32:S31-41 (1995).
Bianchi and Goi, "On the antidiarrheal and analgesic properties of diphenoxylate, difenoxine and loperamide in mice and rats." Arzeneimittel-Forschung/Drug Research 27(1),5,1040-1043 (1977).
Buerkle et al., "Comparison of the spinal actions of the .mu.-opioid remifentanil with alfentanil and morphine in the rat", Anesthesiology 84(1):94-102 (1996).
Burkhardt et al., "Metkephamid (Tyr-D-Ala-Gly-Phe-N(Me)Met-NH.sub.2), a potent opoid peptide: Receptor binding and analgesic properties." Peptides 3:869-871 (1982).
Chemical Abstr. 100:17470j (1984), citing lizuka et al., "Pharmacodynamics of a new antidiarrheic nufenoxole", Jitchuken Zenrinsho Kenkyho 9(1): 19-41 (1983).
Chemical Abstr. 105:208764w (1986), citing DE 3,545,981 (Jul. 10, 1986).
Chemical Abstr. 111:17521d (1989), citing Shaw et al., "ICI 204448: A .kappa.-opoid agonist with limited access to the CNS", Br. J. Pharmacol. 96(4): 986-992 (1989).
Chemical Abstr. 118:124404j (1993), citing EP 512,902 (May 3, 1991).
Chemical Abstr. 120:116860f (1994), citing Japanese patent JP 05,286,851 (Nov. 2, 1993).
Chemical Abstr. 120:289632 (199

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