Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Derived from transgenic multicellular eukaryote
Patent
1995-06-05
1998-10-20
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Derived from transgenic multicellular eukaryote
4241401, 4241441, 4241561, 424 851, 53038885, 5303896, A61K 39395, A61K 3819
Patent
active
058243046
ABSTRACT:
The invention provides methods for peripheralizing CD34.sup.+ cells, including hematopoietic stem cells. In a first aspect, the method comprises the step of administering a blocking agent of VLA-4 antigen on the surface of CD34.sup.+ cells. In a second aspect, the method comprises administering a blocking agent of VLA-4 antigen on the surface of CD34.sup.+ cells and administering a stimulating agent of CD34.sup.+ cell proliferation in vivo. The method according to the invention is useful in the treatment of cancer or AIDS, and in gene therapy.
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Feisee Lila
Flynn Kerry A.
Johnson Nancy A.
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