Peripheral vasodilating agent containing piperidine derivative a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514307, 514309, 514316, 514322, 514324, 514329, 546139, 546141, 546187, 546193, 546198, 546199, 546201, 546202, A61K 31445, C07D40114, C07D40506, C07D40914

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active

061368261

ABSTRACT:
The present invention relates to novel peripheral vasodilating agents characterized by each containing as an active ingredient, a piperidine derivative or pharmaceutically acceptable salt thereof having excellent peripheral vasodilating activity.
Said piperidine derivative or pharmaceutically acceptable salt thereof is represented by the general formula (1): ##STR1## (wherein R, R.sup.1 and R.sup.2 are the same as defined above.

REFERENCES:
patent: 3330641 (1967-07-01), Woods
patent: 5686610 (1997-11-01), Palmer
Caroon et al. Antihypertensive 1-acyl-4-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethylamino]piperidines, CA 106:207384, 1987.
Essawi et al. "Synthesis and evaluation of 1- and 2-substituted fentanyl analogs for opioid activity" CA 98:161161, 1983.
Terada et al. "Piperidine derivatives" CA 106:18371, 1985.

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