Peripheral-type benzodiazepine receptor expression level as...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S040500

Reexamination Certificate

active

07615355

ABSTRACT:
The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The invention provides a method for determining an index of organ health in the course of transplantation therapy comprising measuring the expression level of peripheral-type benzodiazepine receptor (PBR) in the organ. Measuring the expression level of PBR is also useful for assessing the progress of organ regeneration in the course of transplantation therapy by comparing the index of organ health. The expression level of PBR may be used as a predictor of the outcome of transplantation therapy.

REFERENCES:
patent: 2002/0102604 (2002-08-01), Edwards et al.
Hauet et al., “Modulation of Peripheral-Type Benzodiazepine Receptor Levels in a Reperfusion Injury Pig Kidney-Graft Model,”Transplantation,Dec. 15, 2002, pp. 1507-1515, vol. 74, No. 11.

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