Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-04-22
2009-11-10
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S040500
Reexamination Certificate
active
07615355
ABSTRACT:
The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The invention provides a method for determining an index of organ health in the course of transplantation therapy comprising measuring the expression level of peripheral-type benzodiazepine receptor (PBR) in the organ. Measuring the expression level of PBR is also useful for assessing the progress of organ regeneration in the course of transplantation therapy by comparing the index of organ health. The expression level of PBR may be used as a predictor of the outcome of transplantation therapy.
REFERENCES:
patent: 2002/0102604 (2002-08-01), Edwards et al.
Hauet et al., “Modulation of Peripheral-Type Benzodiazepine Receptor Levels in a Reperfusion Injury Pig Kidney-Graft Model,”Transplantation,Dec. 15, 2002, pp. 1507-1515, vol. 74, No. 11.
Hauet Thierry
Papadopoulos Vassilios
Buchanan Ingersoll & Rooney P.C.
Georgetown University
Pak Michael
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