Peripheral-type benzodiazepine receptor: a tool for...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C435S252300, C435S069100, C536S023100, C536S024500, C514S04400A

Reexamination Certificate

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09047652

ABSTRACT:
The expression and subcellular localization of peripheral-type benzodiazepine receptors (PBR) is shown in this application to correlate with the metastatic potential of cells, and increased cell proliferation. Inhibition of PBR expression, function or stability results in a decrease in cell proliferation. Compositions and methods for regulating and/or monitoring PBR and its expression are useful for the detection, diagnosis, prognosis and treatment of solid tumors, in particular, breast cancer.

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