Peripheral myelin protein coding sequence and method

Details Peripheral myelin protein coding sequence and method Peripheral myelin protein coding sequence and method

1995-08-21

1997-02-04

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4351723, 935 11, C12N 1512

Patent

active

055999204

ABSTRACT:
The disclosed invention includes a a peripheral myelin protein, PMP-22, which is present predominantly in the peripheral nervous system and purified nucleic acids which encode the protein. Also included are oligonucleotide probes and primers derived from such sequences, and methods for the use of such sequences, probes and primers in detecting peripheral neuropathies.

REFERENCES:
Kitamura et al (1976) Biochim. Biophys. Acta. 455 806-816.
Spreyer et al. (1991) EMBO. J. 10: 3661-3668.
Uyemura et al. (1978) Adv. Exp. Biol. Med. 100 95-115.
Snipes et al (1992) J. Cell Biol. 117: 225-238.
Manfioletti et al. (1990) Mol. Cell. Biol. 10: 2924-2934.
Welcher et al. (1991) Proc. Nat. Acad. Sci, USA, 88 7195-7199.

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