Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-05-22
1997-06-10
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3155
Patent
active
056375824
ABSTRACT:
There is disclosed (-)-cis-1,5-benzothiazepine represented by the following formula or pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 represents lower alkyl or lower alkoxy; R.sup.2 represents hydrogen or lower alkanoyl; R.sup.3 represents lower alkyl; R.sup.4 represents hydrogen or lower alkyl; R.sup.5 represent hydrogen, lower alkyl or hydroxy lower alkyl; and A represents lower alkylene,
which is a prophylactic and/or curing agent of Raynaud's disease and chronic arterial obstruction.
REFERENCES:
patent: 3562257 (1971-02-01), Kugita
Kanazawa et al, J. Cardiovascular Pharmacol., 16 (3), pp. 430-437, 1990.
Remington's Pharmaceutical Sciences, 16th edition, 198, p. 420, 1980.
Week 8411, Derwent Publications Ltd., London, GB; AN 84-065035 & JP-A-59 020 221 (Tanabe Seiyaku Co., Ltd.), 1984.
Niceritrol, Pharmacological Studies on Niceritrol (10), The Effects on Experimental Models of Peripherally Circulatory Insufficiency, pp. 859-866, 1982.
S. Nishio et al. Effect of Beraprost Sodium on Peripheral Circulatory Disturbances Induced by Various Stimuli Arzneim.-Forsch./Drug Res. 39 (II), Nr. 10 (1989).
Derek J. Trezise et al. Cromakalim does not protect against skeletal muscle fatigue in an anasthetized rat model of acute hindlimb ischaemia, European Journal of Pharmacology, 250 (1993) pp. 109-116.
Kaburaki Minako
Murata Sakae
Narita Hiroshi
Spivack Phyllis G.
Tanabe Seiyaku Co. Ltd.
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