Peripheral benzodiazepine receptor ligands as antiinflammatory a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514221, A61K 3147

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active

057769460

ABSTRACT:
Compounds which bind with high affinity to peripheral benzodiazepine receptors are useful as antiinflammatory agents. Such compounds include isoquinoline and benzodiazepine derivatives, such as PK 11195. A method of treating an inflammatory condition in a mammal with such compounds is provided. Pharmaceutical compositions comprising such compounds are provided. A method is provided for identifying compounds that are therapeutically effective for treating inflammatory conditions.

REFERENCES:
patent: 4788199 (1988-11-01), Benvides et al.
patent: 4788204 (1988-11-01), Benavides et al.
patent: 4808599 (1989-02-01), Dubroeucq et al.
patent: 5185442 (1993-02-01), Weber et al.
patent: 5192753 (1993-03-01), McGeer et al.
patent: 5488064 (1996-01-01), Sher
patent: 5550124 (1996-08-01), Gee
Bartlett et al., Development of Autoimmunity in MRL/1pr Mice and the Effects of Drugs on this Murine Disease, Scand J Rheumatol--Suppl 1988; 75:290-299.
Bessler et al., Immunomodulatory Effect of Peripheral Benzodiazepine Receptor Ligands on Human Mononuclear Cells, J Neurimmunol 1992; 38: 19-26.
Diorio et al., Peripheral Benzodiazepine Binding Sites in Alzheimer's Disease Frontal and Temporal Cortex, Neurobiol Aging 1991; 12: 255-258.
Doble et al., Labelling of Peripheral-type Benzodiazepine Binding Sites in Distribution,Brain Res Bull 1987; 18; 49-61.
Hayashi et al., Pathogenesis of Sjorgren's Syndrome-Like Autoimmune Lesions
Hirsch et al., Characterization of Ligand Binding to Mitochodrial Benzodiazepine Receptors, Mol Pharmacol 1989; 35: 164-172.
Junck et al., PET Imaging of Human Gliomas with Ligands for the Peripheral Benzodiazepine Binding Site, Ann Neurol 1989; 26 752-758.
Klegeris et al., Inhibiton of Respiratory Burst in Macrophages by Complement Receptor Blockade, Eur J Pharmacol 1994; 260: 273-277.
Koopman et al., The MRL-1pr Mouse. A Model for the Study of Rheumatoid
Lenfant et al., In vivo Immunomodulating Activity of PK 11195, a Structurally Unrelated Ligand for Peripheral Benzodiazepine Binding Sites. I. Potentiation in Mice of the Humoral Response to Sheep Red Blood Cells, Int. J. Immunopharmacol 1986; 8, 825-828.
Leong et al., Increased Densities of Binding Sites for the Regions of the Rat Brain in Thiamine Deficient Encephalopathy, J Cereb Blood Flow Metab 1994; 14: 100-105.
McGeer et al., Peripheral-type Benzodiazepine Binding in Alzeheimer Disease, Alz Dix Assoc Disorders 1988; 2: 331-336. 11195 Binding in Rat Cerebral Cortex Following a Local Ischaemic Lesion, J. Cerebral Blood Flow Metab 1991; 11: 314-322.
Ramsier et al., In vitro Inhibition of Cellular Immune Responses by Benzodiazepines and PK 11195, Immunopharmacol Immunotoxicol 1993; 15: 557-582.
Ratkay et al., Photodynamic Therapy: a Comparison with other Immunomodulatory Treatments of Adjuvant-enhanced Arthritis in MRL-1pr Mice, Clin Exp Immunol 1994; 95: 373-77.
Ratkay et al., Complete Freund's Adjuvant Induces an Earlier and More Severe Arthritis in MRL-1pr Mice, J Immunol 1993; 151:5081-5087.
Rosenberg, Neuromuscular Histopathology in (New Zealand Black .times. New Zealand White) F1 and MRL-1pr Autoimmune Mice: Models for Skeletal Muscle Involvement in Connective Tissue, Disease, Arthritis Rheumatism 1988; 31: 806-811.
Sakic et al., Brain-Reactive Antibodies and Behavior of Autoimmune MRL-1pr Mice, Physiol Behavior 1993; 54: 1025-1029. 5-4864 in Rat Brain and Kydney, J Pharm Exp Ther 1983; 225: 61-69.
Synder et al., Molecular Mechanism of Peripheral Benzodiazepine Recepators, Neurchem Res 1990; 15: 1992-123.
Vogelweid et al., Inflammatory Central Nervous System Disease in Lups-prone MRL/1pr Mice: Comparative histologic and Immunohistochemical findings, J Neuroimmunology 1991; 35; 89-99.
Zavala et al., Interaction of Benzodiazepines with Mouse Macrophages, Eur J Pharmac 1984; 106: 561-566.
Zavala et al., Peripheral Benzodiazepines Enhance the Respiratory Burst of Macrophage-Like P33D1 Cells Stimulated by Arachidonic Acid, Int J Neuropharmac 1987a; 9: 269-274.
Zavala et al., Benzodiazepines and PK 11195 Expert Immunomodulating Activities by Binding on a Specific Receptor on Macrophages, Ann NY Acad Sci 1987b; 496; 240-249.
Zisterer et al., The Effects of the Peripheral-Type Benzodiazepine Acceptor Ligand, Ro 5-4864 and PK 11195, on mitochondrial Respiration, Meth. Find. Clin. Pharmacol. 1992.
Klegeris et al., Rat Brain Microglia and Peritoneal Macrophages Show Similar Responses to Respiratory Burst Stimulants, J Neuroimmunology 1994; 53: 83-90.
Sprengel et al., Molecular Cloning and Expression of cDNA Encoding a Peripheral-Type Benzodiazepine Receptor, JBC 1989; 264(34): 20415-20421.
Parola et al. Cloning and Expression of a Pharmacologically Unique Bovine Peripheral-type Benzodiazepine Receptor Isoquinoline Binding Protein, JBC 1991; 266(21): 14082-14087.
Taketani et al., Induction of Peripheral-type Benzodiazepine Receptors during Differentiation of Mouse Erythroleukemia Cells, JBC 1994; 269(10): 7527-7531.
Toupin et al, Lymphokine & Cytokine Research, vol. 4 pp. 7-14 (1990).

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