Periocular drug delivery for diabetic retinopathy

Details Periocular drug delivery for diabetic retinopathy Periocular drug delivery for diabetic retinopathy

2007-07-24

2007-07-24

Woodward, Michael P. (Department: 1615)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

C424S400000, C424S427000

Reexamination Certificate

active

10375973

ABSTRACT:
This invention provides reagents and methods for delivering insulin, insulinomimetic agents, and the like to a vertebrate eye via subconjunctival routes, sub-Tenon's routes, or intravitreal routes for treatment of nerve-related vision disorders such as diabetic retinopathy, and formulations useful in the practice of the disclosed methods.

REFERENCES:
patent: 5182258 (1993-01-01), Chiou
patent: 5457109 (1995-10-01), Antonucci et al.
patent: 6090839 (2000-07-01), Adams et al.
patent: 6160000 (2000-12-01), Adams et al.
J. Ambatl; C. Canakis; J.Miller; E. Gragoudas; A. Edwards; D. Weissgold; I. Kim; F. Delori; A. Adamis, “Diffusion of High Molecular Weight Compounds through Sclera,” IOVS, Apr. 2000, vol. 41, No. 5, pp. 1181-1185.
J. Ambatl; E. Gragoudas; J. Miller; T. You; K. Miyamoto; F. Delori; A. Adamis, “Transscleral Delivery of Bioactive Protein to the Choroid and Retina,” IOVS, Apr. 2000, vol. 41, No. 5, pp. 1186-1191.

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