Perhydrothiazepine and perhydroazepine derivatives and their the

Details Perhydrothiazepine and perhydroazepine derivatives and their the Perhydrothiazepine and perhydroazepine derivatives and their the

1987-04-03

1988-10-18

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514 63, 514212, 540487, 540488, 540524, 540527, C61K 3155, A61K 31395, C07D28106, C07D22502

Patent

active

047787902

ABSTRACT:
Compounds of formula (I): ##STR1## (wherein A is an alkylene group substituted by an optionally substituted amino or heterocyclic group and optionally interrupted by an oxygen or sulfur atom, R.sup.2 is various organic groups, B is C.sub.1 -C.sub.2 alkylene and Y is sulfur or methylene) and pharmaceutically acceptable salts and esters thereof are valuable hypotensive agents which may be prepared by a condensation reaction of the corresponding compound having an amino group in place of the group A--CH(COOH)--NH--.

REFERENCES:
patent: 4587050 (1986-05-01), Harris et al.
patent: 4629787 (1986-12-01), Harris et al.
patent: 4666901 (1987-05-01), Parsons
patent: 4680392 (1987-07-01), Harris et al.
patent: 4699905 (1987-10-01), Yanagisawa et al.
patent: 4734410 (1988-03-01), Yanagisawa et al.
Chemical Abstracts vol. 106, Item 32870g (1987) abstracting South African Patent ZA 80 04,755 (Feb. 26, 1986).
Chemical Abstracts vol. 106, Item 78243h (1987) abstracting Thorsett "Actual Chim. Ther.", (1986), vol. 13, pp. 257-268.
Thorsett et al, Peptides Structure and Function, Am. Peptide Symposium (8th: 1983) Univ. of Arizona, pp. 556-588.

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