Liquid purification or separation – With means to add treating material – Chromatography
Patent
1994-10-03
1996-09-03
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
2105021, B01D 1508
Patent
active
055520413
ABSTRACT:
Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves passing fluids through specially designed chromatography matrices at high flow rates. The matrices define first and second interconnected sets of pores and a high surface area for solute interaction in fluid communication with the members of the second set of pores. The first and second sets of pores are embodied, for example, as the interstices among particles and throughpores within the particles. The pores are dimensioned such that, at achievable high fluid flow rates, convective flow occurs in both pore sets, and the convective flow rate exceeds the rate of solute diffusion in the second pore set. This approach couples convective and diffusive mass transport to and from the active surface and permits increases in fluid velocity without the normally expected bandspreading.
REFERENCES:
patent: 3122514 (1964-02-01), Abrams
patent: 3243386 (1966-03-01), Nielsen et al.
patent: 3322695 (1967-05-01), Alfray et al.
patent: 3326875 (1967-06-01), Moore
patent: 3488922 (1970-01-01), Kirkland
patent: 3505785 (1970-04-01), Kirkland
patent: 3728290 (1973-04-01), Johansson et al.
patent: 3782075 (1974-01-01), Kirkland
patent: 3855172 (1974-12-01), Iler et al.
patent: 3862030 (1975-01-01), Goldberg
patent: 4012265 (1977-03-01), Rinde
patent: 4029583 (1977-06-01), Ho Chang et al.
patent: 4070283 (1978-01-01), Kirkland
patent: 4070286 (1978-01-01), Iler et al.
patent: 4102746 (1978-07-01), Goldberg
patent: 4131542 (1978-12-01), Bergna et al.
patent: 4160728 (1979-07-01), Kirkland et al.
patent: 4169014 (1979-09-01), Goldberg
patent: 4186120 (1980-01-01), Ugelstad
patent: 4224415 (1980-09-01), Meitzner et al.
patent: 4245005 (1981-01-01), Regnier et al.
patent: 4247498 (1981-01-01), Castro
patent: 4256840 (1981-03-01), Meitzner et al.
patent: 4297220 (1981-10-01), Meitzner et al.
patent: 4335017 (1982-06-01), Miles et al.
patent: 4336161 (1982-06-01), Rosevear et al.
patent: 4350595 (1982-09-01), Gunkel
patent: 4352884 (1982-10-01), Nakashima et al.
patent: 4382124 (1983-05-01), Meitzner et al.
patent: 4384957 (1983-05-01), Crowder, III et al.
patent: 4385991 (1983-05-01), Rosevear et al.
patent: 4430451 (1984-02-01), Young et al.
patent: 4446314 (1984-05-01), Jordan
patent: 4452892 (1984-06-01), Rosevear
patent: 4477492 (1984-10-01), Bergna et al.
patent: 4483773 (1984-11-01), Yang
patent: 4496461 (1985-01-01), Leeke et al.
patent: 4501826 (1985-02-01), Mortzner et al.
patent: 4512897 (1985-04-01), Crowder, III et al.
patent: 4519909 (1985-05-01), Castro
patent: 4522953 (1985-06-01), Barby et al.
patent: 4549584 (1985-10-01), Morin et al.
patent: 4576199 (1986-03-01), Svensson et al.
patent: 4604198 (1986-08-01), Dailey et al.
patent: 4618533 (1986-10-01), Steuck
patent: 4673734 (1987-06-01), Tayot et al.
patent: 4729834 (1988-03-01), Itoh et al.
patent: 4732687 (1988-03-01), Muller et al.
patent: 4737292 (1988-04-01), Ritacco et al.
patent: 4761232 (1988-08-01), Bright
patent: 4780113 (1988-10-01), Koslow
patent: 4986908 (1991-01-01), Stout et al.
patent: 5019270 (1991-05-01), Afeyan et al.
patent: 5037543 (1991-08-01), Maejima et al.
Abrams, "High Porosity Polystyrene Cation Exchange Resins," Industrial and Engineering Chemistry, 48(9):1469-1472 (1956).
Albright et al., "Ion-Exchange Polymers," Encyclopedia of Polymer Science and Engineering, 8:341-393 (1987).
Albright et al., "Catalysis by Functionalized Porous Organic Polymers," Rohm and Haas Company Publication, Jul. 1985, pp. 1-27.
Albright, "Porous Polymers as an Anchor for Catalysis," Reactive Polymers, 4:155-174 (1986).
Chang et al., "High Speed Ion Exchange Chromatography of Proteins," Analytical Chemistry, 48(13):1839-1845 (1976).
Crispin et al, "Determination of the Pore Size Distribution, by Exclusion Chromatography, of Ion-Exchange Polymers Which Swell in Water," J. Chromatogr., 239:351-362 (1982).
Diemer et al., "Sulfonated Poly(styrene-divinylbenzene) Catalysts; III. The Influence of Polymer Physical Properties on the Kinetics of Methanol Dehydration," Journal of Catalysis, 74:373-381 (1982).
Girmaud et al., "Comparison of Gels Used for Molecular Sieving of Proteins by Electron Microscopy and Pore Parameters Determinations," J. Chromatogr., 166:37-45 (1978).
Gunn, "Axial and Radial Dispersion in Fixed Beds," Chem. Eng. Sci., 48:363-373 (1987).
Gunn, "Axial Dispersion in Packed Beds: The Effect of the Quality of Packing," Trans. Instn. Chem. Engrs., 49:109-113 (1971).
Guyot and Bartholin, "Design and Properties of Polymers as Materials for Fine Chemistry," Prog. Polym. Sci., 8:277-332 (1982).
Haller, "Correlation Between Chromatographic and Diffusional Behaviour of Substances in Beds of Pore Controlled Glass," J. Chromatogr., 32:676-684 (1968).
Horvath and Lin, "Movement and Band Spreading of Unsorbed Solutes in Liquid Chromatography," J. Chromatogr., 126:401-420 (1976).
Horvath and Lin, "Band Spreading in Liquid Chromatography; General Plate Height Equation and a Method for the Evaluation of the Individual Plate Height Contributions," J. Chromatogr., 149:43-70 (1978).
Kirkland, "High-Performance Liquid Chromatography with Porous Silica Microspheres," Journal of Chromatographic Science, 10:503-509 (1972).
Kirkland, "Microparticles with Bonded Hydrocarbon Phases for High-Performance Reverse-Phase Liquid Chromatography," Chromatographia, 8(12):661-668 (1975).
Kirkland, "Porous Silica Microsphere Column Packings for High-Speed Liquid-Solid Chromatography," J. Chromatogr., 83:149-167 (1973).
Kitagawa, "Ion-Exchange Chromatography of Proteins on a Poly-ethyleneimine-Grafted Hydrophilic Polymer for High-Performance Liquid Chromatography," J. Chromatogr., 443:133-141 (1988).
Komiyama and Inoue, "Effects of Intraparticle Flow on Catalytic Reactions," Journal of Chemical Engineering of Japan, 7(4):281-286 (1974).
Kucera, "Contribution to the Theory of Chromatography; Linear Non-Equilibrium Elution Chromatography," J. Chromatogr., 19:237-248 (1965).
Kunin et al., "Macroeticular Ion Exchange Resins," J. Chem. Phys., 305-306 (1962).
Kunin et al., "Two Decades of Macroreticular Ion Exchange Resins," Amber-Hi-Lites, Publication No. 161, Spring 1979, Pp. 1-6.
Leitch et al., "Column Packings for Modern Liquid Chromatography," Journal of Chromatographic Science, 11:105-113 (1973).
Pearson et al., "High-Performance Liquid Chromatography of Proteins and Peptides," pp. 51-123 undated.
Richey, "FPLC: A Comprehensive Separation Technique for Biopolymers," Am. Lab., 14:104-129 (1982).
Rodrigues et al., "Intraparticle Convection, Diffusion and Zero Order Reaction in Porous Catalysts," Chem. Eng. Commun., 27:327-337 (1984).
Rodrigues, "Nonlinear Adsorption, Reaction, Diffusion, and Intraparticle Convection Phenomena in Flow Systems," pp. 147-180. Undated.
Rounds et al., "Poly(Styrene Divinylbenzene)-Based Strong Anion-Exchange Packing Material for High-Performance Liquid Chromatography of Proteins," J. Chromatogr., 397:25-38 (1987).
Rounds et al., "Factors Contributing to Intrinsic Loading Capacity in Silica-Based Packing Materials for Preparative Anion-Exchange Protein Chromatography," J. Chromatogr., 362:187-196 (1986).
Rohm and Haas, "Ion Exchange Resins Laboratory Guide," Mar. 1988, pp. 1-43.
Schneider and Smith, "Adsorption Rate Constants from Chromatography," AIChE Journal, 14:762-771 (1968).
Seipke et al., "High-Pressure Chromatography (HPLC) of Proteins," Angew. Chem. Int. Ed. Engl., 25:535-552 (1986).
Soderberg et al., "Fast Protein Separations on Mono O.TM., Mono S.TM. and Mono P.TM.," Protides Biol. Fluids, 30 pp. 635-640 (1983).
Tsiveriotis, Konstantinos G., "Convection Inside a Porous Microbial Particle As A Means Of Nutrient Transport," submitted to Department of Chemical Engineering in partial fulfillment of requirements for the degree of Master of Science in Chemical Engineering at the Massachusetts Institute of Technology, Jun., 1988; received by MIT Library, Nov. 14, 1988, pp. 1-46.
Van Deemter et al., "Longitudinal Diffusion and Resistan
Afeyan Noubar B.
Dean, Jr. Robert C.
Regnier Fred E.
PerSeptive Biosystems Inc.
Therkorn Ernest G.
LandOfFree
Perfusive chromatography does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Perfusive chromatography, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Perfusive chromatography will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1947934