Perfusion device with hepatocytes

Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435240241, 435240242, 435240243, 435284, 435285, 435311, 604 4, C12N 508, C12M 300

Patent

active

050432605

ABSTRACT:
A perfusion device to grow and maintain hepatocytes including a chamber having a perfusion inlet and a perfusion outlet, a semipermeable membrane in the chamber defining separate perfusion and hepatocyte compartments, and hepatocytes in the hepatocyte compartment attached via oligosaccharide-lectin recognition linkage to a biopolymer support in the hepatocyte compartment.

REFERENCES:
patent: 3734851 (1973-05-01), Matsumura
patent: 4853324 (1989-08-01), Viles et al.
patent: 4869826 (1989-09-01), Wang et al.
Pharmacia Fine Chemicals, publication entitled, "Affinity Chromatography", 1983, pp. 52-61.
Wolf, C. F. W., and Munkelt, B. E., "Bilirubin Conjugation by an Artificial Liver Composed of Cultured Cells and Synthetic Capillaries", vol. XXI, Trans. Amer. Soc. Artif. Int. Organs, 1975, pp. 16-23.
Jauregui, H. O., et al., "Hybrid Artificial Liver", in Szycher, M. (ed.), Biocompatible Polymers, Metals, and Other Composites (Lancaster, Pa., Technomic Pub), 1983, pp. 907-928.
Jauregui, H. O., et al., "Adult Rat Hepatocyte Cultures as the Cellular Component of an Artificial Hybrid Liver", in Paul, J. P. (ed.), Biomaterials in Artificial Organs, (MacMillan), 1983, pp. 130-140.
Hager, J. C., et al., "Neonatal Hepatocyte Culture on Artificial Capillaries, A Model for Drug Metabolism and the Artificial Liver", ASAIO J., 6:26-35, (Jan./Mar. 1983).
Steer, C. J., et al., "Studies on a Mammalian Hepatic Binding Protein Specific for Asialoglycoproteins", Journal of Biological Chemistry, vol. 255, No. 7. Apr. 10, 1980, pp. 3008-3113.
Curtis, A. S. G., et al., "Substrate Hydroxylation and Cell Adhesion", J. Cell Science, vol. 86, 1986, pp. 9-24.
Schnabel, W., Polymer Degradation, (Munich, 1981).
Hatten, M. E., and Francois, A. M., "Adhesive Specificity of Developing Cerebellar Cells on Lectin Substrata", Developmental Biology, vol. 87, 1981, pp. 102-113.
Seglen, P. O., "Preparation of Isolated Rat Liver Cells", Chapter 4, from Methods in Cellular Biology, 13:29-83, (1976).
McMillan, P. N., et al., "Light and Electron Microscope Analysis of Lectin Binding to Adult Rat Liver in Situ", Laboratory Investigation, vol. 50, No. 4, (1984), pp. 408-420.
Weigel, P. H., et al., "Specific Adhesion of Rat Hepatocytes to .beta.-Galactosides Linked to Polyacrylamide Gels", Journal of Biological Chemistry, vol. 253, No. 2, Jan. 25, 1978, pp. 330-333.
Weigel, P. H., et al., "Adhesion of Hepatocytes to Immobilized Sugars", Journal of Biological Chemistry, vol. 254, No. 21, Nov. 10, 1979, pp. 10830-10838.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Perfusion device with hepatocytes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Perfusion device with hepatocytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Perfusion device with hepatocytes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1413729

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.