Perfluorocarbon associated gas exchange

Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas

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12820418, 128913, A61M 1500

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054372720

ABSTRACT:
Method and means for maintaining respiratory gas exchange, by introducing into the pulmonary air passages of a mammalian host a volume of perfluorocarbon liquid substantially equivalent to the pulmonary functional residual capacity of the host, maintaining respiratory gas exchange in the perfluorocarbon liquid-laden pulmonary air passages by continuous positive pressure breathing with a conventional respirator, for up to an hour or more, and thereafter evaporating the perfluorocarbon liquid from the pulmonary air passages. Useful for treating pulmonary surfactant deficiency or dysfunction.

REFERENCES:
patent: 3975512 (1991-06-01), Long
patent: 4036210 (1977-07-01), Campbell et al.
patent: 4825859 (1989-05-01), Lambert
patent: 5024995 (1991-06-01), Robertson et al.
patent: 5029580 (1991-07-01), Radford et al.
Greenspan, et al., "Liquid Ventilation of Preterm Baby", Lancet, Nov. 4, 1989, p. 1095.
Widjaja, et al., "Mechanical Properties of Isolated Fetal Miniature Pig Lungs After Substitution . . . ", Res. Exp. Med., 188:425-432 (1988).
Waldrop, "The (Liquid) Breath of Life", Science, 245:1043-1045 (1989).
Richman, et al., "Lung Lavage with Oxygenated Fluoracarbon Improves Gas Exchange and Lung Compliance in Cats with Acute Lung Injury", 1990 World Conference on Lung Health, Category 26.
Curtis, et al. "Airway and Alveolar Pressures During Perfluorocarbon Breathing in Infant Lambs" J. Appl. Physiol. 68: 2322-2328 (1990).
Curtis, et al. "Cardiac Output During Liquid (Perfluorocarbon) Breathing in Newborn Piglets" Crit. Care Med. 19(2): 225-230 (1991).
Merritt, et al. "Exogenous Surfactant Treatments for Neonatal Respiratory Distress Syndrome and their Potential Role in the Adult Respiratory Distress Syndrome" Drugs 38(4): 591-611 (1989).
Nakayama, et al. "Pulmonary Dysfunction in Surgical Conditions of the Newborn Infant" Crit. Care Med. 19(7): 926-933 (1991).
Ravenscraft, et al. "Components of Excess Ventilation in Patients Initiated on Mechanical Ventilation" Crit. Care Med. 19(7): 916-925 (1991).
Richman, P. "Lung Lavage with Oxygenated Fluorocarbon Improves Gas Exchange and Lung Compliance in Cats with Acute Lung Injury" 1990 World Conference on Lung Health.
Riess, J. "Reassessment of Criteria for the Selection of Perfluorochemicals for Second-Generation Blood Substitutes: Analysis of Structure/Property Relationships" Aritificial Organs 8(1):44-56 (1984).
Shaffer, et al. "The Effects of Liquid Ventilation on Cardiopulmonary Function in Preterm Lambs" Chest Res. 7:303-306 (1983).
Yokoyama, et al. "A Perfluorochemical Emulsion as an Oxygen Carrier" Artificial Organs 8(1):34-40 (1984).
Klystra, J. A., et al., Of mice and fish Transactions of the American Society for Artificial Internal Organs 8:378-383, 1962.
Reufer, R., Surfactant and alveolar surface forces after breathing of an inert fluoridated liquid, Federation Proceedings 29(5):1813-1815, 1970.
Clark, L. C., and F. Gollan, Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure, Science 152:1755-1756, 1966.
Biro, P. B., and P. Blais, Perfluorocarbon blood substitutes, CRC Critical Reviews in Oncology/Hematology 6(4):311-374, 1987.
Modell, J. H., et al., Long-term survival of dogs after breathing oxygenated perfluorocarbon liquid, Federation Proceedings 29(5):1731-1739, 1970.
Modell, J. H., et al., Liquid ventilation of primates, Chest 69:79-81, 1976.
Calderwood, H. W., et al., Residual levels and biochemcial changes after ventilation with perfluorinated liquid, Journal of Applied Physiology 139:603-607, 1975.
Forman, D., et al., A fine structure study of the liquid-ventilated new rabbit, Federation Proceedings 43:647, 1984.
Rufer, R., and L. Sbitzer, Liquid ventilation in the respiratory distress syndrome, Chest 66(Suppl):29-30, 1974.
Puchetti, B., et al., Liquid ventilation in man: first clinical experiences on pulmonary unilateral washing fluorocarbon liquid, Fourth World Congress for Bronchology (Abstracts), p. 115, 1984.
Shaffer, T. H., A brief review: liquid ventilation, Undersea Biomedical Research 14(2):169-179, 1987.
Shaffer, T. H., et al., The effects of liquid ventilation on cardiopulmonary function in preterm lambs, Pediatric Research 17:303-306, 1983.
Shaffer, T. H., et al., Physiological effects of ventilation with liquid fluorocarbon at controlled temperatures, Undersea Biomedical Research 11(3):287-298, 1984.
Lowe, C. A., and T. H. Shaffer, Increased pulmonary vascular resistance during liquid ventilation, Undersea Biomedical Research 8(4):229-238, 1981.
Gollan, F., and L. C. Clark, Prevention of bends by breathing an organic liquid, Transactions of the Association American Physicians 29:102-109, 1967.
Sass, D. J., et al., Liquid breathing: prevention of pulmonary arteriovenus shunting during acceleration, Journal of Applied Physiology 32:451-455, 1972.
Avery, M. E., and J. Mead, Surface properties in relation to atelectasis and hyaline membrane disease, Am J Dis Child 97:517, 1959.
Pattle, R. E., et al., Inability to form a lung-lining film as a cause of the respiratory-distress syndrome in the newborn, Lancet ii:469, 1962.
Holm, B. A., and S. Matalon, Role of pulmonary surfactant in the development and treatment of adult respiratory distress syndrome, Anesth Analg 69(6):805, 1989.
Wolfson, M. R., et al., A new experimental approach for the study of cardiopulmonary physiology during early development, J Appl Physiol 65(3):1436, 1988.
Greenspan, J. S., et al., Liquid ventilation of human preterm neonates, J Pediatr 117(1 Part 1):106, 1990.
Fuhrman, B. P., Perfluorocarbon liquid vetilation: the first human trial, J Pediatr 117(1 Part 1):73, 1990.
Shaffer, T. H., et al., Cardiopulmonary function in very preterm lambs during liquid ventilation, Pediatr Res 17:680, 1983.
Barrow, R. E., Volume-pressure cycles from air and liquid filled intact rabbit lungs, Respiration Physiology 63:19, 1986.
Avery, M. E., et al., The inflationary force produced by pulmonary vascular distension of excised lungs: the possible relation of this force to that needed to inflate the lungs at birth, J Clin Invest 38:456, 1959.
Avery, M. E., and B. D. Fletcher, The Lung and Its Disorders in the Newborn Infant, Third Edition, Philadelphia, WB Saunders, p. 216, 1974.
Calderwood, H. W., et al., Pulmonary lavage with liquid fluorocarbon in a model of pulmonary edema, Anesthesiology 38(2):141A, 1973.
Shaffer, T. H., et al., Pulmonary lavage in preterm lambs, Pediatr Res 12:695, 1978.
Shaffer, T. H., and G. D. Moskowitz, Demand-controlled liquid ventilation of the lungs, J Appl Physiol 36:208, 1974.
Gollan, F., et al., Compliance and diffusion during respiration with fluorocarbon fluid, Federation Proceedings 29(5):1725, 1970.
Shaffer, T. H., et al., Gaseous exchange and acid-base balance in premature lambs during liquid ventilation since birth, Pediat Res 10:227, 1976.
Shaffer, T. H., et al., Liquid ventilation: effects on pulmonary function in distressed meconium-stained lambs, Pediat Res 18(1):47, 1984.
Fuhrman, B. P., et al., Perfluorocarbon (PFC) associated gas exchange (PAGE), Pediat Res 29(4 Part II):28A, abstract 199, Apr. 1991.

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