Perfluorobutane ultrasound contrast agent and methods for its ma

Stock material or miscellaneous articles – All metal or with adjacent metals – Composite; i.e. – plural – adjacent – spatially distinct metal...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 952, A61B 800, A61K 4900

Patent

active

057018995

ABSTRACT:
The invention relates to a new ultrasound contrast agent of the type which relies on microbubbles for echogenicity. The new contrast agent comprises microbubbles with an internal atmosphere enhanced with a perfluorobutane gas which is effective for visually detecting myocardial uptake upon echocardiogram following peripheral intravenous injection of said agent into a host. The contrast agent of this invention is unique in that it makes possible the non-invasive visual detection of myocardial uptake. In addition, the contrast agent of this invention makes feasible safe and consistent, non-invasive methods for visually assessing, qualitatively or quantitatively, not only myocardial perfusion, but renal and hepatic perfusion, and for detecting severity of coronary arterial stenosis.

REFERENCES:
patent: 4572203 (1986-02-01), Feinstein
patent: 4634586 (1987-01-01), Goodwin et al.
patent: 4718433 (1988-01-01), Feinstein
patent: 4774958 (1988-10-01), Feinstein
patent: 4844882 (1989-07-01), Widder et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 5040537 (1991-08-01), Katakura
patent: 5107842 (1992-04-01), Levene et al.
patent: 5255683 (1993-10-01), Monaghan
patent: 5304325 (1994-04-01), Kaufman et al.
patent: 5310540 (1994-05-01), Giddey et al.
patent: 5315997 (1994-05-01), Widder et al.
patent: 5315998 (1994-05-01), Tachibana et al.
patent: 5380519 (1995-01-01), Schneider et al.
patent: 5385147 (1995-01-01), Anderson et al.
patent: 5385725 (1995-01-01), Lin et al.
patent: 5393524 (1995-02-01), Quay
patent: 5401493 (1995-03-01), Lohrmann et al.
patent: 5409688 (1995-04-01), Quay
patent: 5410516 (1995-04-01), Uhlendorf et al.
patent: 5413774 (1995-05-01), Schneider et al.
patent: 5439686 (1995-08-01), Desai et al.
patent: 5445813 (1995-08-01), Schneider et al.
patent: 5540909 (1996-07-01), Schutt
patent: 5542935 (1996-08-01), Unger et al.
patent: 5552133 (1996-09-01), Lambert et al.
patent: 5558853 (1996-09-01), Quay
patent: 5560364 (1996-10-01), Porter
patent: 5567415 (1996-10-01), Porter
Porter, "The Mechanism and Clinical Implication of Improved Left Ventricular Videointensity Following Intravenous Injection of Multi-Fold Dilutions of Albumin With Dextrose", Int. J. Card Imaging, Jun. 1995, vol. 11, No. 2, pp. 117-25, XP000590839.
Xie F. et al., "Acute Myocardial Ischemia and Reperfusion Can be Visually Identified Non-Invasively with Intraveneous Perfluoropropane-Enhanced Sonicated Dextrose Albumin Ultrasound Contrast", Abstract No. 2989, 67th Scientific Sessions of the American Heart Assoc., Dallas, TX, USA, Nov. 14-17, 1994. Circulation, 1994, vol. 90, No. 4 part 2, p. 1555, XP000577054.
Porter, et al., "Echocardiographic Detection of Residual Coronary Flow Abnormalities and Stenosis Severity After Coronary Reperfusion Using Intravenous Perfluoropropane-Enhanced Sonicated Dextrose Albumin", Abstract No. 955-60, 44th Annual Scientific Session of the American College of Cardiology, New Orleans, LA, USA, Mar. 19-22, 1995. In: Journal of the American College of Cardiology, Spec. Issue, p. 205A., XP000577058.
Putterman, S., "Sonoluminescence: Sound into Light", Feb. 1995, Scientific American, 46-51.
Evans, W., 1992, Chapter 5, "Influence of Protein Binding", 3rd Ed., Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring.
Kumar, S., 1995, "Characterization of Binding Sites, Extent of Binding, and Drug Interactions of Oligonucleotides with Albumin", Antisense Research and Development, 5:131-139, Mary Ann Liebert, Inc.
Kricsfeld et al, "Detection of Regional Perfusion Abnormalities During Adenosine Stress Echocardiography Using Intraveneous Perfluoropropane-Enhanced Sonicated Dextrose Albumin", Abstract No. 703-2, 44th Annual Scientific Session of the American College of Cardiology, New Orleans, LA, USA, Mar. 19-22, 1995. In: Journal of the American College of Cardiology, Spec. Issue, p. 38A, XP000577057.
Porter, et al, "Multifold Sonicated Dilutions of Albumin with Fifty Percent Dextrose Improve Left Ventricular Contrast Videointensity After Intravenous Injection in Human Beings", abstract, J. Am. Soc. Echocardiogr., Sep.-Oct. 1994, vol. 7, No. 5, pp. 465-71, XP000590864.
Xie, et al, "Perfluoropropane Enhanced Sonicated Dextrose Albumin Produces Visually Apparent Consistent Myocardial Opacification With Physiologic Washout and Minimal Hemodynamic Changes Following Venous Injection", Apstract No. 362, 67th Scientific Sessions of the American Heart Association, Dallas, TX, USA, Nov. 14-17, 1994, In: Circulation, 1994, vol. 90, No. 4, Part 2, p. 269,, XP000577055.
Porter, et al, "Visually Discernible Myocardial Echocardiographic Contrast After Intravenous Injection of Sonicated Dextrose Albumin Microbubbles Containing High Molecular Weight, Less Soluble Gases", abstract, J Am Coll Cardiol, Feb. 1995, vol., 25, No. 2, pp. 509-15, XP000590866.
Porter, et al, Noninvasive Identification of Acute Myocardial Ischemia and Reperfusion With Contrast Ultrasound Using Intravenous Perfluoropropane-Exposed Sonicated Dextrose Albumin, abstract, J Am Coll Cardiol, Jul. 1995, vol. 26, No. 1, pp. 33-40, XP000590865.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Perfluorobutane ultrasound contrast agent and methods for its ma does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Perfluorobutane ultrasound contrast agent and methods for its ma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Perfluorobutane ultrasound contrast agent and methods for its ma will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-194716

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.