Perfluoro-t-butyl-containing compounds for use in fluorine-19 NM

Details Perfluoro-t-butyl-containing compounds for use in fluorine-19 NM Perfluoro-t-butyl-containing compounds for use in fluorine-19 NM

1989-07-31

1992-05-26

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 5, 436173, 514 23, 514759, 536 11, 536 184, G01N 3100, G01N 2400, C07H 100, C07H 1500

Patent

active

051165996

ABSTRACT:
Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance.

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