Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1993-03-26
1995-03-28
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 1286534, 554 20, 514533, 514751, 514754, 514832, 570182, A61B 5055, A61K 3103, C07C 2200
Patent
active
054014930
ABSTRACT:
Organic compounds for diagnostic imaging which contain at least one aryl group which has been derivatized to contain at least one perfluoro-1H,1H-neopentyl moiety are provided. The perfluoro-1H,1H-neopentyl groups produce a single magnetic resonance to insure a maximum signal to noise ratio. One compound disclosed is 2-O-oleoylglycerol 1,3-bis(7'-{3",5"-di[2"',2"'-di(trifluoromethyl)3"', 3"',3"'-trifluoropropyl]phenyl}heptanoate). In the preferred embodiment, a lipid emulsion is provided as a carrier vehicle to deliver the derivitized analog to a mammalian recipient. Methods to use these compounds in MRI and computerized tomography are provided.
REFERENCES:
patent: 4110474 (1978-08-01), Lagow et al.
patent: 4187252 (1980-02-01), Lagow et al.
patent: 4535184 (1985-08-01), Middleton
patent: 4558279 (1985-12-01), Ackerman et al.
patent: 4612185 (1986-09-01), Dean
patent: 4647447 (1987-03-01), Gries et al.
patent: 4760173 (1988-07-01), Klaveness
patent: 4775522 (1988-10-01), Clark, Jr.
patent: 4943595 (1990-07-01), Sharer et al.
patent: 4957939 (1990-09-01), Gries et al.
patent: 5116599 (1992-05-01), Rogers, Jr. et al.
Smart et al. J. Am. Chem. Soc. 108:4905-7 (1986).
Dyatkin Russian Chemical Reviews 45(7):607-14 (1976).
Eidelberg et al. Magn. Res. in Medicine 6:344-52 (1988).
James B. Martin, "Preparation of Saturated and Unsaturated Symmetrical Monoglycerides," The J. of the American Chem. Soc., 75:5482 (1953).
Rodgers, et al., Synthesis of Reporter Groups for Fluorine-19 NMR: A New Class of Imaging and Spectroscopic Compounds, Abstracts of the Eigth Annual Meeting of the Society of Magnetic Resonance in Medicine (1989) 2:819.
Weichert, et al., Evaluation of Aryl 3,5-Bistrifluoromethylated Compounds as Potential Fluorine NMR Spectroscopy and Imaging Agents, Abstracts of the Seventh Annual Meeting of the Society of Magnetic Resonance in Medicine (1988) 1:484.
Krishnan Ashwin
Lohrmann Rolf
Hollinden Gary E.
Molecular Biosystems, Inc.
LandOfFree
Perfluoro-1H,-1H-neopentyl containing contrast agents and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Perfluoro-1H,-1H-neopentyl containing contrast agents and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Perfluoro-1H,-1H-neopentyl containing contrast agents and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2248756