Percutaneous treatment with a high potency non-steroidal anti-in

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

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Details

514887, 514941, 514943, 514947, A61K 910

Patent

active

051046563

ABSTRACT:
To prepare an analgesic, anti-inflammatory cream, ibuprofen-S is dissolved in the PEG-7-glycerylcocoate and propylene glycol by slightly warming the solution to about 40 degrees Centigrade. Fractionated coconut oil, di-isopropyladipate, stearic acid, cetyl alcohol, polyoxyl-40-stearate, sorbitan-monostearate and propylparaben are mixed and heated to 70 degrees Centigrade. Methylparaben Sod. is dissolved in demineralized water and heated to 70 degrees Centigrade. The above oil and water phase components are mixed together, cooled to about 50 degrees Centigrade and the ibuprofen-S solution is added to the emulsion. The emulsion is homogenized and cooled to room temperature to form the cream.

REFERENCES:
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patent: 4555524 (1985-11-01), Gruber et al.
patent: 4647586 (1987-03-01), Mizushima et al.
patent: 4720353 (1988-01-01), Bell
patent: 4746675 (1988-05-01), Makino et al.
patent: 4849418 (1989-07-01), Lohner et al.
patent: 4873081 (1989-10-01), Ogiso

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