Percutaneous pharmaceuticals preparation for external use

Details Percutaneous pharmaceuticals preparation for external use Percutaneous pharmaceuticals preparation for external use

1987-03-09

1988-03-15

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514227, 514557, 514929, 514947, 424449, A61L 31535, A61L 3119, A61K 1503

Patent

active

047312416

ABSTRACT:
A percutaneous pharmaceutical preparation for external use containing N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) and an absorption promoter selected from the group consisting of aliphatic monoalcohols of 10 to 22 carbon atoms, aliphatic monoamides of 8 to 18 carbon atoms and aliphatic monoamines of 10 to 16 carbon atoms gives a high blood concentration of molsidomine over a long time period when applied onto the human skin.

REFERENCES:
patent: 4420470 (1983-12-01), Otsuka et al.
patent: 4421737 (1983-12-01), Ito et al.
Merck, p. 815, No. 6120, 9th ed., 1976.
Chem. Absts., 73:25485g, 1970.
Chemical Abstracts, vol. 69, No. 20, 11th Nov. 1968, p. 7512, No. 80150m, Columbus, Ohio, US; J. Miyazaki et al.: "Corticosteriod Ointments, III Solubilities of Corticosteriods in Some Alkylol Amides and Alkyl Amides", & Yakuzaigaku 1966, 26(3), 196-199.

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