Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-

Details Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3- Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-

1988-05-25

1989-12-05

Kight, John

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514558, 514560, 514724, A61M 700, A61K 3158, A61L 1503, A61F 1300

Patent

active

048851744

ABSTRACT:
Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.

REFERENCES:
patent: 4241084 (1980-12-01), Minuto
patent: 4263313 (1981-04-01), Eckert et al.
patent: 4305936 (1981-12-01), Klein
patent: 4388307 (1983-06-01), Cavanik
patent: 4440777 (1984-04-01), Zupan
patent: 4460372 (1984-07-01), Campbell et al.
patent: 4522872 (1985-11-01), Cooper et al.
patent: 4605548 (1986-08-01), Ushiyama et al.
Journal of Pharmaceutical Sciences, vol. 74, No. 6, pp. 688-689.
Beyer, C., et al., "Mikroemulsionen", Pharmazie in unserer Zeit, 12. Jahrg. 1983, Nr. 2.
Reifenrath, W. G., et al., J. Environ. Path. Toxicol., 4/1 pp. 249-256, 1980.
Reinfenrath, W. G., et al., Fd. Cosmet. Toxicol., vol. 19, pp. 195-199, 1981.
Reinfenrath, W. G., and Robinson, P. B., Journal of Pharmaceutical Sciences, vol. 71, No. 9, pp. 1014-1018, Sep. 1982.
Stenback, F., Toxicology and Applied Pharmacology 30, pp. 7-13, 1974.
Washitake, M., et al., Journal of Pharmaceutical Sciences, vol. 64, No. 3, pp. 397-401, Mar. 1975.
Abstract 7508420 for Patent 3883661 to Young on May 13, 1975.
Abstract 83073709 052002040097 for Hofer, H. et al., Food Chem. Toxicol., 20/6, pp. 921-923, 1982.
Chemical Abstract 96(22)187298a for EP 43738 Jan. 13, 1982.
Chemical Abstract 103: 27198C (1985).

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