Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-

Details Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3- Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-

1989-09-26

1991-01-08

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514724, 514947, A61F 1300, A61K 970, A61K 31045, A01N 3100

Patent

active

049833960

ABSTRACT:
Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.

REFERENCES:
patent: 4241084 (1980-12-01), Minuto
patent: 4764381 (1988-08-01), Bodor et al.
patent: 4885174 (1989-12-01), Bodor et al.
Reifenrath et al., "Percutaneous Penetration of Mosquito Repellents in the Hairless Dog: Effect of Dose on Percentage Penetration", Fd. Cosmet. Toxicol., vol. 19, pp. 195-199, 1981.

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