Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3

Details Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3 Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3

1985-12-06

1988-08-16

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514509, 514947, A61L 1503, A61F 1300, A61K 906, A61K 3121

Patent

active

047643811

ABSTRACT:
Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.

REFERENCES:
patent: 4322433 (1982-03-01), Leslie et al.
patent: 4557934 (1985-12-01), Cooper
patent: 4605548 (1986-08-01), Ushiyama et al.
patent: 4654209 (1987-03-01), Leslie et al.
Cooper et al., I CA. 103 #59235d(1985) of J. Pharm. Sci. 74(6): 688-9 (1985).
Bennett et al., CA. 103 #27200x(1985) of J. Pharm. Pharmacol. 37(5).298-304 (1985).
Yamada et al., CA. 102 #100807m(1985) of EPO 127468 Dec. 5, 1984 17 pp.
Uda et al., CA. 102 #100808n(1985) of EPO 127426 Dec. 5, 1984 19 pp.
Cooper II CA. 102 #119657j(1985) of EPO 129285 Dec. 27, 1984 60 pp.
Cooper, III CA. 100 #91365v(1984) of EPO 95813 Dec. 7, 1983 23 pp.
Cooper et al., II CA. 102 #84443g 1985 of EPO 129283 Dec. 27, 1984 40 pp.
Wickett et al., CA. 96 #187298a 1982 of EPO 43738 Jan. 13, 1982 39 pp.

Affiliated with

Also associated with

Rating

Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-599880