Percutaneous drug delivery system

Details Percutaneous drug delivery system Percutaneous drug delivery system

1994-03-21

1996-07-09

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514946, 514947, A61F 1300

Patent

active

055342604

ABSTRACT:
A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e.g. 1-substituted-azacycloheptan-2-one), and propylene glycol to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drug(s); occluding the area of skin during the application; and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the described treatment.

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Sales Brochure for the Capital stock of Noven Pharmaceutical, Inc.
"Noven Pharmaceutical, Inc.", Barron's, p. 59, Sep. 19, 1988.
Package insert of Nitro-Dur (nitroglycerin) Transdermal Infusion System, Sep. 1987.
Package insert for Transderm SCOP Transdermal Therapeutic System Nov. 1985.
Package insert for the Transderm-Nitro Transdermal Drug Delivery System Jul. 1987.

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