Percutaneous drug delivery system

Details Percutaneous drug delivery system Percutaneous drug delivery system

1992-03-24

1994-03-22

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424449, 424 9464, 424 9465, 424 9466, 424 941, 514946, 514947, A61K 3754

Patent

active

052962229

ABSTRACT:
A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e.g. 1-substituted-azacycloheptan-2-one), and propylene glycol to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drug(s); occluding the area of skin during the application; and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the described treatment.

REFERENCES:
patent: 4666441 (1987-05-01), Andriola et al.
patent: 4837026 (1989-06-01), Rajakhyaksha
patent: 4859696 (1989-08-01), Kamiya et al.
patent: 4911707 (1990-03-01), Heiber et al.
patent: 4917676 (1990-04-01), Heiber et al.

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