Percutaneous-administration-type pharmaceutical preparation of n

Details Percutaneous-administration-type pharmaceutical preparation of n Percutaneous-administration-type pharmaceutical preparation of n

1988-03-31

1990-11-20

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424443, A61F 1302

Patent

active

049717995

ABSTRACT:
A percutaneous-administration-type pharmaceutical preparation of nitroglycerin comprising a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is disposed on one surface of the backing, wherein the pressure-sensitive adhesive layer contains alkyl (meth)acrylate copolymer in the concentration of 80-95% by weight and the nitroglycerin in the concentration of 5-20% by weight, said copolymer contains as major copolymer components alkyl (meth)acrylate with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexylmethacrylate in the concentration of 40-90% by weight based on the total weight of said alkyl (meth)acrylates, and the copolymer has a rolling ball tack value of 2 or less. The preparation obtained makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for long periods of time.

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WO 8201317, 4/82 from 424/448.
Patent Abstracts of Japan, vol. 7, No. 155 (C-175) [1300], Jul. 7th, 1983; & JP-A-58 67 776 (Sekisui Kagaku Kogyo K.K.) 22-04-1983.
Patent Abstracts of Japan, vol. 6, No. 154 (C-119) [1032], Aug. 14th 1982; & JP-A-57 75 917 (Nichiban K.K.) 12-05-1982.
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