Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1980-11-03
1982-03-30
Cassiapaglia, Jr., Frank
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424343, 260467, A61K 3121
Patent
active
043224334
ABSTRACT:
A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on the total weight of the preparation. The composition may also contain other medicaments, the bioavailability of which is enhanced by the nitroglycerine. The action of the preparation against for example angina may be brought about by having an appropriate amount of nitroglycerine or as additional medicament another medicament active against angina. The preparation may contain an hydroxyalkylcellulose which may provide, in combination with a waxy component in the cream, for example a higher aliphatic alcohol, a prolonged release effect. The preparation has advantages particularly as regards bioavailability over prior uniphasic ointments.
REFERENCES:
patent: 3609102 (1971-09-01), Schlossman
Nitrol.RTM. Ointment, package insert, 10/77.
Lachman et al., "Theory and Practice of Industrial Pharmacy", 2nd ed. 1976, pp. 215-244.
Boroda Cyril
Halpern Alfred
Leslie Stewart T.
Rhodes Alan
Cassiapaglia, Jr. Frank
Euroceltique S.A.
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