Percutaneous absorption type preparation

Details Percutaneous absorption type preparation Percutaneous absorption type preparation

1998-12-02

2000-09-12

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 514947, 514946, A61K 970

Patent

active

061174475

ABSTRACT:
A percutaneous absorption type preparation comprising a support and a plaster layer laminated thereon, which composes tulobuterol in a proportion of not less than 5 wt % in a dissolution state and an adhesive. The preparation of the present invention retains the active ingredient, tulobuterol, at a high concentration in a complete dissolution state in the plaster layer. Therefore, it is free of time-course changes in drug releasing property and adhesive property caused by precipitation of drug crystals with the lapse of time. The inventive preparation is superior in percutaneous absorption of the drug, particularly percutaneous absorption rate at the initial stage of the administration; shows superior duration of efficacy by maintaining effective blood concentration for a long time; and is associated with less changes with the lapse of time in adhesive property such as adhesion to the skin.

REFERENCES:
patent: 5254348 (1993-10-01), Hoffmann et al.
patent: 5300291 (1994-04-01), Sablotsky et al.
patent: 5312627 (1994-05-01), Stroppolo et al.
patent: 5571530 (1996-11-01), Nakano et al.
patent: 5639472 (1997-06-01), Yamamoto et al.
patent: 5683710 (1997-11-01), Akemi et al.
Chemical Abstracts, vol. 126, No. 8, Feb. 24, 1997, XP-002116852.

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