Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1988-10-05
1992-06-09
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 25, 514171, 514273, 514109, 514420, 514451, 514454, 514518, 514559, 514730, 514947, 514975, A61K 4700, A61K 906, A61K 970
Patent
active
051207168
DESCRIPTION:
BRIEF SUMMARY
DESCRIPTION
1. Technical Field
This invention relates to a percutaneous absorption promoting agent and a dermatologic preparation containing said percutaneous absorption promoting agent. More particularly, the present invention relates to a percutaneous absorption promoting agent comprising (A) at least one anionic surfactant and one or two or more of surfactants having a nitrogen atom in the molecule other than anionic surfactants, (B) one or two or more of anionic surfactants and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, (C) one or two or more of surfactants selected from the group consisting of amphoteric surfactants and semi-polar surfactants and at least one nonionic surfactant having a nitrogen atom in the molecule, (D) one or two or more of surfactants selected from the group consisting of nonionic surfactants, amphoteric surfactants, semi-polar surfactants and cationic surfactants having a nitrogen atom in the molecule, and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, or (E) an amine oxide as the active ingredient, and dermatological preparation containing these percutaneous absorption promoting agent and drug components.
2. Background Art
Heretofore a drug component has been administered by oral administration, administration by injection, intramuscular or intravenous administration, administration to intestine or mucosa within the mouth, etc. Among them, oral administration has been most widely practiced. However, in the case of oral administration, drawbacks have occurred such that the concentration has become temporarily higher than is necessary to ensured persistence of the effect and that side effects such as stomach disorder or lack of appetite may be caused. On the other hand, although absorption is rapid in administration by injection, this must be made by an expert such as physician, etc.
Recently, dermatologic preparations by percutaneous administration have been developed to eliminate such side effects and drawbacks. However, even in such dermatologic preparations, a sufficient percutaneous absorptivity has not been yet obtained in most cases, and therefore, they are not considered satisfactory.
Further, the surface of the skin is called the skin corneum layer, which has in itself a physiological function as a barrier for protection against the penetration of foreign matter from outside of the body, and therefore, a sufficient percutaneous absorptivity can not be obtained by merely formulating a drug component in a base conventionally used in the prior art in a dermatologic preparation.
To improve this factor, various percutaneous absorption promoting agents have been proposed in recent years. For example, dimethyl sulfoxide, dimethylformamide, dimethylacetamide, methyldecyl sulfoxide, etc., are known, but these cannot be considered to have a sufficient percutaneous absorption promoting effect, safety and use feeling.
DISCLOSURE OF THE INVENTION
Accordingly, an object of the present invention is to solve the problems of the prior art as mentioned above and provide a percutaneous absorption promoting agent having an excellent percutaneous absorption promoting effect of a drug component, and further satisfactory with respect to safety and use feeling another object of the present invention is to provide a dermatologic preparation comprising the percutaneous absorption promoting agent and a drug component, which is an excellent percutaneous absorption agent promoting the effect of the drug component and further, is satisfactory with respect to safety and use feeling.
Other objects and advantages of the present invention will be apparent from the following description.
That is, the present invention provides a percutaneous absorption promoting agent for a drug component, comprising one or two or more of anionic surfactants and one or two or more of surfactants having a nitrogen atom in the molecule other than the anionic surfactants as the active ingredients and a dermatologic preparation containing a
REFERENCES:
patent: 2914441 (1959-11-01), Zakheim
patent: 4329334 (1982-05-01), Su et al.
patent: 4384974 (1983-05-01), Guthauser
patent: 4536519 (1985-04-01), Wuest et al.
patent: 4537772 (1985-08-01), Alexander et al.
patent: 5023085 (1991-06-01), Francoeur et al.
Chiba Tadahiro
Iwata Yuhei
Miyazawa Kiyoshi
Murotani Isao
Tamaki Shuya
Shah Mukund J.
Shiseido Company Ltd.
Ward E. C.
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