Percutaneous absorption preparation

Details Percutaneous absorption preparation Percutaneous absorption preparation

1987-03-26

1989-10-10

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Lymphokine

514220, 514419, 514420, 514946, 514947, A61K 3140, A61K 3154, A61K 3178

Patent

active

048730815

ABSTRACT:
A percutaneous absorption preparation which comprises calcium salt of an acidic anti-inflammatory or analgesic drug having carboxyl group as the active ingredient and present in an amount of 0.3-10% by weight; a medium for the active ingredient which is selected form the group consisting of an ethylene glycol mono-lower alkyl ether, propylene glycol, polyethylene glycol and dimethylsulfoxide, the medium being present in an amount at least sufficient to dissolve the active ingredient; an absorption promotor selected from the group consisting of 1-dodecylazacycloheptan-2-one, hexamethylenelauramide, N-methyl-2-pyrrolidone, a sucrose aliphatic acid ester, dimethylsulfoxide and a nonionic surfactant and present in an amount of 0.5-10% by weight; and the remaining being other reagents and/or carriers required for a desired form of the preparation.

REFERENCES:
patent: 3953599 (1976-04-01), Kilmer et al.
patent: 4309414 (1982-01-01), Inagi et al.
patent: 4507287 (1985-03-01), Dixon
patent: 4540572 (1985-09-01), Seth
patent: 4543251 (1985-09-01), Kamishita
patent: 4545992 (1985-10-01), Kamishita
patent: 4710497 (1987-12-01), Hella et al.

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