Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1998-09-03
2000-10-17
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
A61F 1302
Patent
active
061327611
ABSTRACT:
The present invention provides a percutaneous absorption preparation which hardly causes the coloration phenomenon and is excellent in the stability of the drug content. The percutaneous absorption preparation comprises a support and a pressure-sensitive adhesive layer formed on at least one side of the support, wherein the pressure-sensitive adhesive layer contains a percutaneous absorptive drug and at least one of 2-mercaptobenzimidazole and propyl gallate, with the proviso that the percutaneous absorptive drug is not 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole and pharmacologically acceptable salt thereof.
REFERENCES:
Sokolowska, Regina, Identification of Antioxidants Used for Polyethylene, Rocz. Panstw, Zakl. Hig., (1966), 17(5), pp. 439-446.
Ninomiya, Kazuhisa, et al., Transdermal Tapes Containing Polymeric Base with Pharmaceuticals and Their Stabilizer, Propyl Gallate, Jpn. Kokai Tokkyo Koho, 7pp, Jun. 1987.
Kale, P. et al., "Preformulation Stability and Permeation Studies of Transdermal Patches of Salbutamol," Indian Journal of Pharmaceutical Sciences, Sep.-Oct. 1996, pp. 211-215.
Kenji, H., "Composition for Heat-Resistant Self-Welding Crosslinked Polyolefin Tape," Patent Abstracts of Japan, Oct. 27, 1983.
Akira, M., "Adhesive Tape," Patent Abstracts of Japan, Oct. 11, 1980.
Akemi, H., et al., "Percutaneous agent contain mercapto benzimidazole stabilized amino chloro isopropyl methyl piperazinyl benzimidazole adhesive layer control side effect chemotherapy," Japanese Abstract, 1997.
Ninomiya, K., et al., "Transdermal tapes containing polymeric base with pharmaceuticals and their stabilizer, propyl gallate," Japanese Abstract, 1988.
Akemi Hitoshi
Inosaka Keigo
Ishitani Hiroko
Muraoka Takateru
Otsuka Saburo
Dees Jos,e G.
Nitto Denko Corporation
Williamson Michael A.
Woods McGuire
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