Peptomers with enhanced immunogenicity

Details Peptomers with enhanced immunogenicity Peptomers with enhanced immunogenicity

1995-01-19

1998-05-12

Knode, Marian G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

514 2, 514 13, 435974, C12Q 170, A61K 3810

Patent

active

057503320

ABSTRACT:
The present invention relates to synthetic peptide analogues useful as therapeutic agents, immunogens or for the diagnosis of disease. In particular, it relates to peptide multimers which maintain the conformation of the native proteins from which they are derived. Peptomers constructed from peptides derived from gp120 of the human immunodeficiency virus are exemplified.

REFERENCES:
patent: 5066716 (1991-11-01), Robey et al.
patent: 5109123 (1992-04-01), Reinherz et al.
patent: 5128319 (1992-07-01), Arlinghaus
patent: 5185147 (1993-02-01), Papsidero
Robey, F.A., et al. (1994) "Use of peptomers to study the binding of HIV-1 to CD4: Effects of polymerication on the biology and chemistry of a synthetic peptide", Peptides: Chemical, Structure and Biology, Proc. Am Pept. Symp., 13th, Meeting date 1993;924-926.
Robey, F.A., et al. (1992) "Peptomers as Vaccine Candidates", Genetically Engineered Vaccines, 327:209-215.
Joklik et al., Zinsser Microbiology, 20th Edition. Appleton & Lange, Norwalk, conn., 1992, pp. 1053-1054.
Fahey et al., Status of Immune-based therapies in HIV infection and AIDS, Clin. exp. Immunol. 88:1-5, 1992.

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