Peptoid mixtures

Details Peptoid mixtures Peptoid mixtures

1995-05-10

1998-09-22

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514 19, 52631841, 526302, 526314, A61K 3802

Patent

active

058113878

ABSTRACT:
Mixtures of peptoids are provided. The subject peptoid mixtures comprise at least five non-homopolymeric polymers of differing sequences having a selected number of monomer units. The polymers of the subject mixtures are preferably selected from the group of compounds of the general formula: X.sub.a --(NR--CH.sub.2 --CO).sub.n --X.sub.b, X.sub.a --(O--CHR--CO).sub.n --X.sub.b, X.sub.a --(NH--CHR--CS).sub.n --X.sub.b, X.sub.a --(NOH--CHR--CO).sub.n --X.sub.b, X.sub.a --(O--CHR--CH.sub.2 --CO).sub.n --X.sub.b, X.sub.a --(NH--CHR--CH.sub.2 --SO.sub.2).sub.n --Xb, Xa--(NR--CH.sub.2 CH.sub.2 --SO.sub.2).sub.n --X.sub.b, X.sub.a --(NR--CH.sub.2 CH.sub.2 --NHCO).sub.n --X.sub.b and X.sub.a --(NR--CH.sub.2 CH.sub.2 --OCO).sub.n X.sub.b, where each R is independently a side chain capable of interaction with a protein, carbohydrate, lipid or nucleic acid; n is an integer from 2 to 50, inclusive; and X.sub.a and X.sub.b are each independently H, lower alkyl, lower aryl, aralkyl, lower acyl, a polypeptide of 1-100 amino acids, or an effector molecule capable of exhibiting biological activity.

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Zuckerman, Ronald et al., "Efficient Method for the Preparation of Peptoids Chemtracts-Macromolecular Chemistry (1993) vol. 4:80-83.
Kasica, H. et al., "Electrical Condictivity of N-Substituted Polyamides", Journal of Polymer Science Part A-1 (1968) vol. 6:1615-1623.
Cosani A. et al., "N-Substituted Poly (-amino acids). 1. Synthesis and Characterization of Poly (N-methyl-y-mehtyl L-Glutamate) and Poly (N-methyl-Y-ethyl L-glutamate).sup.1 ", Macromolecules (1978) vol. 11 No. 5; 1041-1045.

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