Peptidyl t-RNA hydrolase (PTH)

Details Peptidyl t-RNA hydrolase (PTH) Peptidyl t-RNA hydrolase (PTH)

2007-04-10

2007-04-10

Martinell, James (Department: 1634)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S196000, C530S350000

Reexamination Certificate

active

10437581

ABSTRACT:
The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 6420135 (2002-07-01), Kunsch et al.
patent: 6800744 (2004-10-01), Doucette-Stamm et al.
patent: 0906958 (1999-09-01), None
De La Vega, et al., “Microbial genes homologous to the peptidyl-tRNA hydrolase-encoding gene ofEscherichia coli,” Genevol. 169, No. 1, pp. 97-100, (Feb. 22, 1996).
Database Swissport- Database Accession No. P37470 “Peptidyl-tRNA hydrolase” (XP002204363).
Schmitt, et al., “Crystal structure at 1.2 A resolution and active site mapping ofEscherichia colipeptidyl-tRNA hydrolase,”The EMBO Journal, vol. 16, No. 15, pp. 4760-4769 (1997).
Ogasawara, et al., “Systematic Sequence of the 180 Kilobase Region of theBacillus subtilisChromosome Containing the Replication Origin”, DNA Research, vol. 1, pp. 1-14, (1994).
Dutka, et al., “Role of the 1-72 Base Pair in tRNAs for the Activity ofEscherichia colipeptidyl-tRNA hydrolase”, Nucleic Acids Research, vol. 21. No. 17, pp. 4025-4030, (1993).
Heurgue-Hamard, et al., “The Growth Defect inEscherichia coliDeficient in Peptidyl-tRNA hydrolase is Due to Starvation for Lys-tRNA,” The EMBO Journal, vol. 15, No. 11, pp. 2826-2833, (1996).
Schmitt, et al., “Crystal Structure at 1.2 A Resolution and Active Site Mapping ofEcherichia coliPeptidyl-tRNA Hydrolase”, The EMBO Journal, vol. 16, No. 15, pp. 4760-4769, (1997).
Freifelder, D., Physical Biochemistry, Second Edition, published 1982 by W.H. Freeman and Company, New York, USA, pp. 17-34, see especially p. 20.
Fukunaga, R., et al., “Expression Cloning of a Receptor for Murine Granulocyte Colony Stimulating Factor”, Cell, vol. 61, pp. 341-350, Apr. 20, 1990.

Affiliated with

Also associated with

Rating

Peptidyl t-RNA hydrolase (PTH) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptidyl t-RNA hydrolase (PTH), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptidyl t-RNA hydrolase (PTH) will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3736018