Peptidyl prodrugs and methods of making and using the same

Details Peptidyl prodrugs and methods of making and using the same Peptidyl prodrugs and methods of making and using the same

1996-07-31

1999-09-14

Celsa, Bennett

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 18, 514 19, 4241851, 4241931, 424457, 536 231, A61K 3803, A61K 39385, C07K 500

Patent

active

059522941

ABSTRACT:
Peptidyl prodrugs of therapeutic agents having an activating function are sclosed. These therapeutic agents having activating functions include those having an amino, thiol, or hydroxyl function. Methods of making and using these prodrugs are also disclosed.

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Wipf et al., Biorg. & Med. Chem. Lett. vol. 1 No. 12 pp. 745-750 (1991).
Balajthy et al., J. Med. Chem. (1992) vol. 35 pp. 3344-3349.

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