Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-07-12
2011-07-12
Cordero Garcia, Marceal M (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C548S433000, C530S391700
Reexamination Certificate
active
07977465
ABSTRACT:
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
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Astafieva Irina
Gangwar Sanjeev
Li Zhi-Hong
McGee Danny P. C.
Moore Jimmie
Cordero Garcia Marceal M
Desai Pankaj N.
Medarex Inc.
Nelson Mullins Riley & Scarborough LLP
Remillard, Esq. Jane E.
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