Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-24
1996-05-07
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514255, 514311, 514307, 514471, 514314, 514332, 514340, 514252, 514253, 514427, 514397, 514399, 514422, 514424, 514274, 514263, 514365, 514393, 546175, 546140, 546146, 546337, 546335, 544336, 544312, 544350, 548562, 5483381, 548518, 548550, 548204, 5483041, 549501, C07K 5062, C07K 5065, C07K 5068, C07K 5072, C07K 5075, C07K 5078, A61K 3805
Patent
active
055146945
ABSTRACT:
A novel class of peptide .alpha.-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula Y--CO--AA.sup.2 --AA.sup.1 --CO--NH--X. Processes for the synthesis of peptidyl .alpha.-ketoamide derivatives.
REFERENCES:
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Hu, Arch, Biochem, Biophys., 281, pp. 271-274 (1990).
Burkhart, Tetrahedron Lett., 29, pp. 3433-3436 (1988).
Angelastro, J. Med. Chem, 33, pp. 11-13 (1990).
Chu Der-Lun
Li Zhaozhao
Patil Girish S.
Powers James C.
Cross Laura R.
Georgia Tech Research Corp
McKane Joseph K.
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