Peptidyl heterocyclic ketones useful as tryptase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S241000, C514S247000, C514S248000, C514S255060, C514S266100, C514S301000, C514S307000, C544S216000, C544S224000, C544S235000, C544S237000, C544S256000, C544S283000, C544S355000, C544S406000, C546S114000, C546S116000

Reexamination Certificate

active

07132418

ABSTRACT:
The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.

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