Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1998-10-27
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514365, 514367, 548236, 5483335, 548200, 548255, 5483094, 546314, 546315, A61K 31425, A01N 4378
Patent
active
058278664
ABSTRACT:
Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.
REFERENCES:
patent: 5380713 (1995-01-01), Balasubramanian et al.
patent: 5492895 (1996-02-01), Vlasuk et al.
patent: 5523308 (1996-06-01), Costanzo et al.
patent: 5612369 (1997-03-01), Bone et al.
patent: 5637599 (1997-06-01), Levy et al.
Maryanoff et al. "Cyclotheonamide derivatives: synthesis and thrombin inhibition. Exploration of specific structure-function issues". Bioorganic & Medicinal Chemistry. vol. 3, No. 8, pp. 1025-1038, 1995.
Maryanoff et al. "Macrocyclic peptide inhibitors of serine proteases. Convergent total synthesis of cyclotheonamides A and B via late-stage primary amine intermediate. Study of thrombin inhibition under diverse conditions". J. Am. Chem. Society. vol. 117, 1995.
Mathews et al. "Structure-based design of protease inhibitors". Acta. Cryst. D51, pp. 550-559, 1995.
Matthews et al. "Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site". Biophysical Journal. vol. 71, pp. 2830-2839, Nov. 1996.
Costanzo Michael J.
Maryanoff Bruce E.
Knode Marian C.
Lee Datquan
Ortho Pharmaceutical Corporation
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