Peptidyl derivatives as inhibitors of interleukin-1.beta. conver

Details Peptidyl derivatives as inhibitors of interleukin-1.beta. conver Peptidyl derivatives as inhibitors of interleukin-1.beta. conver

1993-06-02

1995-07-18

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530331, 562571, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

054342481

ABSTRACT:
Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##

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