Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-11-03
1999-03-30
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514740, 5142382, 514255, 514256, 514357, 514365, 514372, 514374, 514378, 514399, 514406, 514428, 514438, 514461, 544106, 544168, 544242, 544335, 544358, 544400, 546336, 546348, 548205, 548214, 548236, 548240, 5483351, 5483381, 5483751, 5483761, 548561, 548562, 548579, 549 76, 549496, 562442, 562450, 562553, 562561, 562567, 562621, 564123, 564152, A61K 3119, A61K 31195, C07C22904, C07C22924, C07C22928, C07C23305, C07C23308, C07C23706
Patent
active
058890580
ABSTRACT:
Methods of use for compounds of formula (I) are described wherein R represent a --CONHOH, carboxyl (--CO.sub.2 H) or esterified carboxyl group; R.sup.1 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, aryl, aralkyl, heteroaralkyl or heteroarylthioalkyl group; R.sup.2 represents an optionally substituted phenylethyl, phenylpropyl or phenylbutyl group; R.sup.3 represents a hydrogen atom or an alkyl group; R.sup.4 represents a hydrogen atom or an alkyl group; R.sup.5 represents an optionally substituted alkyl or alkenyl group optionally interrupted by one or more --O-- or --S-- atoms or --N(R.sup.7)-- groups (where R.sup.7 is a hydrogen atom or a C.sub.1-6 alkyl group); X represents an amino (--NH.sub.2), or substituted amino, hydroxyl or substituted hydroxyl group; and the salts, solvates and hydrates thereof. The compounds are metalloproteinase inhibitors and in particular have a selective gelatinase action, and may be of use in the treatment of cancer to control the development of tumour metastases. ##STR1##
REFERENCES:
patent: 5114953 (1992-05-01), Galardy et al.
Beeley Nigel Robert Arnold
Millican Thomas Andrew
Morphy John Richard
Porter John Robert
Celltech Limited
Oswecki Jane C.
Richter Johann
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