Peptidyl compounds having MMP and TNF inhibitory activity

Details Peptidyl compounds having MMP and TNF inhibitory activity Peptidyl compounds having MMP and TNF inhibitory activity

1997-08-08

1999-09-21

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530331, 562445, A61K 3805

Patent

active

059554355

ABSTRACT:
Peptidyl compounds have therapeutic utility via MMP and TNF inhibitory activity.

REFERENCES:
Holmquist, B., B.L. Vallee (1980) Metal-coordinating substrate analogs as inhibitors of metalloenzymes. Chemical Abstracts 92: abstract No. 89874h.
Mori, T. et al. (1979) Comparative studies on protective effect of various sulfhydryl compounds against cell death and DNA strand breaks induced by x-rays in cultured mouse L cells. Chemical Abstracts 91: abstract No. 32686y.
Isomura, Y. et al. (1992) Preparation of amide derivatives as collagenase inhibitors. Chemical Abstracts 117: abstract No. 212156q.
Corey, E.J., S. Hashimoto (1981) A practical process for large-scale synthesis of (S)-5-hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid (5-HETE). Chemical Abstracts 95: abstract No. 24207k.

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