Chemistry of carbon compounds – Dipeptides – e.g. – aspartame – anserine – carnosine – etc.
Patent
1996-05-10
1998-12-29
Nutter, Nathan M.
Chemistry of carbon compounds
Dipeptides, e.g., aspartame, anserine, carnosine, etc.
26099821, 530868, 514 19, C07K 5062, A61K 3855
Patent
active
058536230
ABSTRACT:
The present invention concerns novel mercaptoalkylpeptidyl compounds of formula (I) which are useful inhibitors of matrix metalloproteinase and/or TNF-mediated diseases including degenerative diseases and certain cancers. The invention also concerns methods of treating patients suffering from disorders or diseases which can be attributed to or are associated with matrix metalloproteinase or TNF activity.
REFERENCES:
patent: 5144043 (1992-09-01), Dean et al.
Almquist, R.G. et al. (1991) "Development of peptidomimetric inhibitors of a newly isolated atrial peptide-degrading enzyme" Peptides Chemistry and Biology, Proceedings of the Twelfth American Peptide Symposium, Jun. 16-21, 1991, Cambridge, MA, USA.
Bormans, G. et al. (1993) "Synthesis and Labelling Characteristics of .sup.99m Tc-Mercaptoacetyltripeptides" J. Labelled Compd. Radiopharm. 33(11):1065-1078.
Baxter Andrew Douglas
Dickens Jonathan
Montana John
Owen David Alan
Chiroscience Limited
Nutter Nathan M.
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