Peptidomimetics inhibiting the oncogenic action of p21 ras

Details Peptidomimetics inhibiting the oncogenic action of p21 ras Peptidomimetics inhibiting the oncogenic action of p21 ras

1996-09-20

1999-06-08

Huff, Sheela

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 514171, 514169, 514182, 552575, 552522, A61K 3800

Patent

active

059104783

ABSTRACT:
The present invention provides peptides, cyclized peptides and peptidomimetics which inhibit the oncogenic and/or transforming activity of the p21 ras protein, pharmaceutical compositions containing at least one of the ras-inhibiting peptides, cyclized peptides and peptidomimetics, and methods for inhibiting the ras-mediated oncogenic and/or transformation process in mammalian cells or tissues.

REFERENCES:
patent: 5364851 (1994-11-01), Joran
Brunwin et al. (1971) J. Chem. Soc. C. 3756.
Felix et al. (1978) J. Org. Chem. 43:4194.
Dueholm et al. (1993) Org. Prep. Proc. Int. 25:457.
Kohl et al. (1993) Science 260:1934-1937.
James et al. (1993) Science 260:1937-1942.
Chung et al. (1991) Anticancer Res. 11:1373-1942.
Chung et al. (1992) Exp. Cell Res. 203:329-335.
Hu et al. (1995) Science 268:100-102.
Pincus et al. (1992) Ann. Clin. Lab. Sci. U.S. 22:323-342.
Chung et al. (1992) Biochem. Biophys. Res. Comm. 181:1378-1384.
Haspel et al. (1992) Med. Sci. Res. 20:809-811.
Yamasaki et al. (1994) Biochemistry 33:65-73.

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