Peptidomimetic ligands for cellular receptors and ion channels

Details Peptidomimetic ligands for cellular receptors and ion channels Peptidomimetic ligands for cellular receptors and ion channels

2006-08-29

2008-11-04

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S426000, C514S317000, C548S557000, C546S139000, C546S125000, C546S244000, C540S593000

Reexamination Certificate

active

07446115

ABSTRACT:
One aspect of the present invention relates to novel peptidomometic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands—agonists or antagonists—for various cellular receptors, e.g., G-protein-coupled receptors and opioid receptors, and various cellular ion channels, e.g., sodium and calcium. In certain embodiments, compounds of the present invention preferentially or selectively inhibit sodium or calcium ion channels. In certain embodiments, compounds of the present invention preferentially or selectively agonize or antagonize μ opioid receptors. In certain embodiments, compounds of the present invention preferentially or selectively inhibit sodium or calcium ion channels and agonize or antagonize μ-opioid receptors.

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