Peptidoglycan biosynthetic mure protein from streptocuccus pneum

Details Peptidoglycan biosynthetic mure protein from streptocuccus pneum Peptidoglycan biosynthetic mure protein from streptocuccus pneum

1996-05-29

1998-01-27

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435183, C12N 900

Patent

active

057121087

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the murE stem peptide biosynthetic gene of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the murE enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

REFERENCES:
Daniel, Richard A., et al., J. of General Microbiology, 139:361-370 (1993).
Michaud, Catherine, et al., Eur. J. Biochem., 194:853-861 (1990).
Tao, Jing-Song, et al., Can. J. Microbiol., 35, 1051-1054 (1989).
Jacobs, M.R. (1992) Treatment and Diagnosis of Infections Caused by Drug-Resistant Streptococcus pneumoniae, Clin. Infect. Dis. 15: 119-127, Jan. 1992.
Flouret, B. et al. (1981) Reverse-Phase High-Pressure Liquid Chromatography of Uridine Diphosphate N-Acetylmuramyl Peptide Precursors of Bacterial Cell Wall Peptidoglycan, Anal. Biochem. 114: 59-63, Jan. 1981.

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