Peptidoglycan biosynthetic mura protein from Streptococcus pneum

Details Peptidoglycan biosynthetic mura protein from Streptococcus pneum Peptidoglycan biosynthetic mura protein from Streptococcus pneum

1996-08-01

1997-11-25

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435193, C12N 910

Patent

active

056911610

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murA of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurA enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

REFERENCES:
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Ehrt, S. and Hillen, W. (1994) UDP-N-acetylglucosamine 1-carboxyvinyl-transferase from Acinetobacter calcoaceticus FEMS Microbiol. Lett. 117: 137-142 Jan. 1994.
Fleischmann, R. D. et al. (1995) Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd, Science 269: 496-512 Jul. 1995.
Wanke, C. et al. (1992) The UDP-N-acetylglucosamine 1-carboxyvinyl-transferase of Enterobacter cloacae, FEBS Letters 301: 271-276 Mar. 1992.
Trach K. et al. (1988) Complete Sequence and Transcriptional Analysis of the spoOF Region of the Bacillus subtilis Chromosome, J. Bacteriology 170: 4194-4208, Oct. 1988.
J. Marquardt et al. "Cloning and sequencing of E. coli murZ . . ." J. Bacter. 174, 5748-5752 (1992).
E. Brown et al. "MurA(MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis . . ." J. Bacter. 177, 4194-4197 (1995) .

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